Abstract Objective: Evaluation of COVID-19 during pregnancy and the pregnancy outcomes. Design: A prospective cohort study. Setting: Central First Health Care Cluster (multicentric), Riyadh. Population or Sample: Pregnant women with a singleton pregnancy diagnosed with COVID-19 . Methods: Parameters included: the age of the patient, gestational age at diagnosis, symptoms at presentation (cough, fever), presence of congenital anomalies, IUFD, mode of delivery, presence of PPH, admission to ICU, newborn Apgar s.core, cord PH, need for NICU admission, and the newborn becoming infected with COVID-19. Main Outcome Measures: COVID-19 positive women and adverse maternal and fetal outcome Results: One hundred pregnant, COVID-19-positive women met the inclusion criteria; the average age of participants was 31.2 years (SD ± 6.4). Asymptomatic patients represented 54% of participants. Most of the deliveries occurred at 36 weeks or less as preterm delivery. Cesarean sections represented 55% of our population. The average weight of the newborn was 2.86 ± 0.65SD); however, 23 (26.4 %) of the newborns delivered to a COVID-positive mother became COVID-19 positive. Conclusion: A high rate of preterm labor, miscarriage, cesarean section, and newborn testing positive for COVID-19 were observed among our population. No congenital anomalies related to COVID-19 were observed. Keywords: Pregnancy, COVID 19, Preterm labor, Miscarriage, Saudi Arabia

Initially, there was little data on the safety of immunization against COVID-19 infection in pregnant women. However, previous studies revealed no safety concerns for pregnant women or newborns who received an mRNA COVID-19 vaccine during pregnancy. Therefore, this study aimed to investigate the effects of COVID-19 vaccination on perinatal outcomes. Methods: This cross-sectional study. It started from January 2022 to June 2022. The questionnaire was developed and validated by experts. This study included all women admitted to the postpartum ward who were more than 18 years old and had received the COVID-19 vaccine. The study excluded women without proof of their vaccination status or who could not complete the questionnaire. The primary outcome was the effect of COVID-19 vaccination on gestational age and birth weight. Results: A total of 365 participants. The mean gestational age of the unvaccinated women was 38.83 ± 1.62 weeks (p < 0.001), higher than that of vaccinated women (37.69 ± 2.9 weeks). However, the average birth weight for the unvaccinated women was 2.96 ± 0.4 kg (p = 0.89) and for vaccinated women (2.97 ± 0.66 kg). Conclusion: COVID-19 vaccination, regardless of the type of vaccine received before, during, or after pregnancy, is not associated with any unfavorable perinatal outcomes.