Hazard is a term associated with a substance that is likely to cause an injury in a given environment or situation. Industrial hazards are major occupational health and safety (OHS) issue in Pharmaceutical manufacturing. In recent years chemical safety and the sound management of chemicals have seen great progress at the global level. At the same time, the rapid growth in production and dissemination of both natural and synthetic chemicals has led to concern about their impact on the natural environment, and human health. In this way, the pharmaceutical industry has come to occupy a unique position. Practically no other commercial enterprises present such as a wide variety of potentially toxic exposures or such a rapidly changing advent of new chemical substances. In the pharmaceutical industry, this dynamic situation has been created by the increasing application of organic chemical synthesis as a technique for producing therapeutic substances. This renders the work of the plant physician so instructive. Industrial safety is needed to check all the possible chances of accidents for preventing loss of life and permanent disability of any industrial worker, any damage to machine and material leads to the loss of the whole establishment.
Samples taken from pond water (Padila), river ganga water (Sangam, Allahabad) sewage water (Yamuna drainage) supply water from Municipal Corporation (Daraganj) were found that Ganga water (Sangam) has positive (large, small, medium) plaque formation other pond water, sewage water, supply water from municipal Corporation do not have plaque formation. It can be predict that Ganga water has high presence of S. aureus plaque formation for bacteriophages. Help in therapeutic process, drug target discovery, bacteriophages isolate from environment or Ganga water sample to specifically target pathogenic bacteria and eliminate them from foods. Bacteriophages approved or use in food safety application, genetically engineered phages to specifically target bacterial virulence-associated genes, control multidrug resistant S. aureus, implications in biofilm treatment, the progress in the knowledge about phage genomics, immunobiology and experimental therapy in animals and in humans suggest that phages could become the antibacterial drugs of the 21st century.
Recently it has been growing interest in investing solid state transition forms prepared by different technique. The majority of drugs are administered in solids form. Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor aqueous solubility. Problem of solubility is a major challenge for formulation scientist, which can be resolved by different technological approaches. Simvastatin belong to class of antihyperlipidemic drugs having very low solubility and falls in category II Class of BCS. Polymorphism and solid state transitions change the solid-state property which is significantly influence the performance of the final product such as solubility, Melting Point, Dissolution Rate and flow property. Optimization process like RCM and CCD design was used to study the effect of variables such as solubility and melting point for quality determination of formulation. Solvent evaporation method is used in this study to prepare new transition form. This technique has more advantages and it is preferred method over others such as spray drying, sonication and homogenization. Through the characterized analysis (SEM, XRD, ATR, DSC, Solublity and melting point) of optimised form, given reliably confirmation data that the new solid state transition forms is amorphous form. It is more soluble than crystalline form.
Data integrity is an important current issue for regulators around the world. During inspections a multitude of problems being found by the pharmaceutical regulatory agency because poor practices develop the substandard product for patients. Collection of various types of information and results collectively made in the form of data. This data becomes one of the most valuable assets of any organization but without integrity, this data is not much useful. Accuracy and original data increase the chances of stability and performance of an organization.
The discovery of natural product with therapeutics effect is widely growing interest, especially for the treatment of neurodegenerative diseases such as dementia or alzheimer's disease (AD). As there are no effective treatment is available to prevent the development of these disease, dietary intake of foods or plant-based extracts with antioxidant properties might have beneficial effects on human health and improve brain functions. AD or dementia is a neurodegenerative disease thatcauses neuron cell death, brain to shrink impaired cognitive function and leads to memory loss. It induces alterations in the central nervous system with psychological and physiological negative effects.In the present commentary we discuss whether natural productcould be a novel treatment for AD on the basis current clinical trials conducted, there is evidence to suggest that single herbal drugs formulations may offer certain benefits to the approved drugs. In the last decades, attention to herbal or natural drugs increased, they have become a major focus in the quest for AD remedies and may represent a real promise for curing the disease.