Abstract

Severe hypercholesterolemia mediated by graft-versus-host disease of liver in patients underwent allogeneic hematopoietic stem cell transplantation is a recognized yet overlooked phenomenon. Reports in literature is limited in both adult and pediatric population and none had been reported in Chinese children to date. As lipoprotein X hypercholesterolemia is due to regurgitation of cholesterol and bile salts into systemic circulation rather than overproduction by hepatocytes, usage of statins to downregulate cholesterol synthesis is not effective. Here we report 2 local cases to increase awareness of transplant physicians and endocrinologists of this association and avoid unnecessary and ineffective usage of statins.