ABSTRACT
Severe hypercholesterolemia mediated by graft-versus-host disease of
liver in patients underwent allogeneic hematopoietic stem cell
transplantation is a recognized yet overlooked phenomenon. Reports in
literature is limited in both adult and pediatric population and none
had been reported in Chinese children to date. As lipoprotein X
hypercholesterolemia is due to regurgitation of cholesterol and bile
salts into systemic circulation rather than overproduction by
hepatocytes, usage of statins to downregulate cholesterol synthesis is
not effective. Here we report 2 local cases to increase awareness of
transplant physicians and endocrinologists of this association and avoid
unnecessary and ineffective usage of statins.
Keywords (MeSH terms 2021): lipoprotein-X,
hypercholesterolemia, hyperlipidemias, graft-versus-host disease,
hematopoietic stem cell transplantation
Abstract word count: 99
Main text word count: 1,123
Number of tables: 1
Number of figures: 1