ABSTRACT
Severe hypercholesterolemia mediated by graft-versus-host disease of liver in patients underwent allogeneic hematopoietic stem cell transplantation is a recognized yet overlooked phenomenon. Reports in literature is limited in both adult and pediatric population and none had been reported in Chinese children to date. As lipoprotein X hypercholesterolemia is due to regurgitation of cholesterol and bile salts into systemic circulation rather than overproduction by hepatocytes, usage of statins to downregulate cholesterol synthesis is not effective. Here we report 2 local cases to increase awareness of transplant physicians and endocrinologists of this association and avoid unnecessary and ineffective usage of statins.
Keywords (MeSH terms 2021): lipoprotein-X, hypercholesterolemia, hyperlipidemias, graft-versus-host disease, hematopoietic stem cell transplantation
Abstract word count: 99
Main text word count: 1,123
Number of tables: 1
Number of figures: 1