Abstract
Allergy of type I hypersensitivity affects about 150 million
people in Europe. It is clinically manifested as atopic dermatitis,
conjunctivitis, rhinitis, rhinoconjunctivitis, and allergic asthma.
However, the underlying mechanisms occurring at the gene expression
level remain poorly understood. To address this gap, the transcriptome
of peripheral blood cells from participants with type I hypersensitivity
symptoms was measured to gain insights into mechanisms underlying the
disease. We examined immunological pathways of observed transcriptomic
profiles to examine immune-related alterations in participants with
atopic disorders. A diverse array of enriched pathways and cellular
processes associated with type I hypersensitivity reactions were
identified within domains such as antigen-presenting cells (APCs),
interleukins, mast cells, CD molecules, T helper (Th) and T regulator
(Treg) cells, and B cells. These findings collectively suggest that
disturbances at the gene expression level contribute to immunological
disorders in individuals experiencing allergic manifestations.
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