1median (min–max)2AD – atopic dermatitis
Differential gene expression analysis
We observed 165 differentially expressed gene transcripts (FDR
< 0.2) in group of participants with allergic asthma and
atopic dermatitis (AD), and 50 of these transcripts were up-regulated ,
and 115 down-regulated in relation to the control group (Table 1,
Supplementary Material 1: Figure S1). The number of up- and
down-regulated genes at different FDR levels are shown in Table 2.
Additionally, other 2083 transcripts (p value < 0.05) have
been found altered across all tested groups (subjects with allergy,
allergy without asthma and AD, and subjects with allergic asthma and
AD), from which 254 were identified to be directly involved in immune
pathways using GO database with 7 genes commonly shared in all groups
(Figure 1 and 2, Supplementary Material 2).
Table 2 . Summary of differentially expressed genes in subjects
with allergic asthma and AD at different FDR levels.