Outcome Comparison of KTP laser and CO2 laser excision for Laryngeal
papillomatosis -- A Systematic Review
Abstract
Background: CO2 laser and the 532-nm potassium titanyl phosphate laser
(KTP) were developed to treat Laryngeal papillomatosis (LP); however,
the difference in their outcomes remains unclear. Methods: A systematic
review was conducted through a comprehensive search of three databases.
Results: Overall, the cure rates were 87.25% in the KTP group and
75.98% in the CO2 group (p<0.05). The complications rates were
significantly different between the two groups (p<0.0001). In
addition, there was no significant difference between the recurrence
rates of the CO2 group and the KTP group (10% vs 9.8%). The risks of
bias were 13.1±1.45 and 13.6±1.52 for CO2 group and KTP group
respectively, which indicated the fair quality of evidence. Conclusions:
The available fair-quality evidence suggested that KTP laser excision
may be a better choice for LP. Following evaluations on the benefits of
the two surgical techniques with more high-quality randomized controlled
studies are needed.