Author |
EL |
Characteristics |
Study |
Lesions |
Laser setting |
Outcomes |
Results |
Findings |
CO2 |
|
|
|
|
|
|
|
|
Castillo et al |
D |
N/proc:29/NA
Age:14
months old-84 years old
Gender:10F/19M
|
Retrospective |
Laryngeal
Papillomatosis
|
3-6W continuous power
100-200Hz
repeition rate
|
Complications
HPV
detected
recurrence
remission(No recurrence
occurred within two months)
clearance(No recurrence
occurred within three years)
cure(No recurrence occurred
within five years)
|
n=3/29(10.4%)
n=22/29(75.8%), mainly
HPV6 and
HPV11
n=13/29(44.8%)
n=6/29(20.7%)
n=10/29(34.5%)
n=12/29(41.3%)
|
Papillomatosis is characterised as a pathology with an unpredictable
course and with a low probability of malignancy. CO2 laser surgery has
meant a revolution in symptomatic treatment, but there is presently no
curative treatment |
Dedo et al |
D |
N/proc:109/548
Age:NA
Gender:43F/66M
|
Retrospective |
Laryngeal
Papillomatosis
|
NA |
Compilcations:
acute upper airway
obstruction
anterior glottic
webbing
Remission
Malignant
Degeneration
Death
|
n=2(1.8%)
n=9(8.1%)
n=45(41.3%)
n=3(2.7%)
n=0(0%)
|
Treatment of LP with CO2 laser followed by
podophyllum painting represents a clear advance over traditional
mechanical methods of papilloma removal when voice
quality,
remission rate, and especially incidence of complications, and
occurrences of death are considered
|
Dedo et al |
D |
N/proc:244/548
Age:NA
Gender:81F/163M
|
Retrospective |
Respiratory Papillomas |
20 W
continuous power
0.2 seconds to continuous exposure
time
1 to 2 mm spot siz
|
Compilcations:
anterior glottic
webbing
Remission
Clearance
Cure
Malignant
Transformation
Death
|
n=68(27%)
n=93(37.3%)
n=15(6.1%)
n=43(17.2%)
n=4(1.6%)
n=0(0%)
|
A true cure with elimination of all human papilloma viruses
(particularly types 6 and 11) will not be achieved until a uniformly
effective vaccine or antiviral and immunomodulating agents are developed |
Holler et al |
D |
N/proc:6/90
Age:3-17
years old
Gender:6M
|
Prospective |
Juvenile-onset Recurrent
Respiratory
Papillomastosis
|
NA |
Jitter%
Shimmer%
NHR%
CAPE-V
|
4.57
14.66
0.31
60
|
the data demonstrate a correlation of worsening voice quality with
increased exposure to the CO2 laser |
Koji et al |
D |
N/proc:9/14
Age:30-56
years old
Gender:5M/4F
|
Prospective
validation
|
Recurrent
Respiratory
Papillomastosis
|
2-3w continuous or super pluse power |
Recurrence |
n=3/9(33.3%) |
CO2 TNFLS is feasible as an in-office surgery for patients with
laryngopharyngeal pathologies. The therapeutic outcome is as expected
with advantage of low patient burden and easy to repeat. |
Hu et al |
D |
N/proc:6/10
Age:NA
Gender:NA
|
Retrospective |
Recurrent
Respiratory
Papillomastosis
|
5w power in super pulse with 0.05s on and 0.01s off |
Complication
Incomplete
sugery
Introlerance
|
N=0/10
N=2/10
N=1/10
|
With meticulous patient selection, office-based laryngeal surgery
performed using a carbon dioxide laser appears to be a feasible
treatment option for various types of vocal lesions. |
Preuss et al |
D |
N/proc:64/137
Age:NA
Gender:NA
|
Retrospective |
Recurrent
Respiratory
Papillomastosis
|
25 W |
Complications:
glottic webs,
scar
temporary laryngeal edema
airway
fire
Recurrence, Malignant transformation, Secondary airway
carcinoma
|
n=4/64(6%)
n=2/64
n=0/64
n=3(4%)
|
Laser microsurgery is the
preferential
treatment modality due to the low rate of
severe scarring and a lower tracheostomy rate as compared with laryngeal
microsurgery with cold instruments.
|
Robb |
D |
N/proc:5/11
Age:2.5-23 years
old
Gender:4F/7M
|
Retrospective |
Recurrent
Laryngeal
Papilloma
|
10-30w in intermittent or plused |
Complications
Remission(more than 1
year)
Intractable airway obstruction
|
n=0/11
n=5/11
n=2/11
|
What the laser has to offer over
other
modalities, is the ability frequently to treat the
paediatric larynx, with little risk of post-operative oedema or
bleeding, reduced hospital in-patient stay, and only mild discomfort.
However, even using frequent laser treatment, a small number of severely
affected children will require tracheotomy for incipient or overt
respiratory obstruction
|
Saleh |
D |
N/proc:3/NA
Age:1-7 years
old
Gender:NA
|
Retrospective |
Recurrent
Laryngeal
Papillomatosis
|
8-10w power |
Complications |
n=0/3 |
NA |
Mattot et al |
D |
N/proc:37/595
Age:1-56 years
old
Gender:11F/26M
|
Retrospective |
Laryngeal
Papillomatosis
|
NA |
Complications:
carcinoma of
larynx
bronchial papillomata
Remission
|
n=1/37
n=0/37
n=13/37(35%)
|
The number of operations per year does not correlate with eventual
remission |
KTP |
|
|
|
|
|
|
|
|
Burns et al |
D |
N/proc: 37/55
Age:
23-73 years old
Gender: 16F/21M
|
Prospective
Uncontrolled
|
recurrent
laryngeal
papillomatosis
|
15 ms pulse width
5.25–7.5
J/pulse
2 Hz repetition rate
20–80 J/cm²
fluence
|
Complications
>90
regression(4-12weeks)
75%-89% and 15%-74% regression
|
N:0/51
n=28/35
n=4/35 to
3/35
|
KTP laser procedure is useful and safe for recurrent
papillomatosis. The majority of patients had >90% of
lesion regression at 4 to 12weeks postoperative |
Hung et al |
D |
N/proc: 16/79
Age:
23-73 years old
Gender: 6F/10M
|
Prospective |
Recurrent
respiratory
papillomatosis
|
30–50 ms pulse width
7–8
W
2 Hz repetition rate
|
Complications
VHI-10:
(1)
before operation; (2) after the first operation; (3) after 2 to 5
repeated in-office or in-hospital procedures; (4) after 6 to 10
procedures
CPPs:
(1) before operation; (2)
after the first operation; (3) after 2 to 5 repeated in-office or
in-hospital procedures; (4) after 6 to 10
procedures
GRB:
(1) before operation; (2)
after the first operation; (3) after 2 to 5 repeated in-office or
in-hospital procedures; (4) after 6 to 10 procedures
|
NA
(1) 28.3; (2)12.0; (3)10.1;
(4)11.0
(1) 6.8;
(2)10.5; (3)10.9;
(4)11.3
(1) 5.0;
(2)2.4; (3)2.4; (4)1.4
|
KTP laser can be an effective tool for managing RRP. Voice quality can
be well preserved even after a dozen KTP laser procedures |
Kaluskar et al |
D |
N/proc: 9/NA
Age:
39-58 years old
Gender: 2F/7M
|
Prospective
Uncontrolled
|
Inverted
papilloma of the nose and paranasal sinuses |
8 W of
power in continuous mode
at least 80% calibration
|
Compilcations
Recurrence (1 year)
|
n=0/9
n=1/9
|
KTP laser is a good
option in view of the low rates of recurrerice and the minimal
postoperative morbidity |
Wei et al |
D |
N/proc:18/33
Age:12-68
years old
Gender:F3/M15
|
Retrospective |
Recurrence
Laryngeal
Papilloma
|
6w of power |
Complications
Cure
Effective(tumour
remission rate>50%)
Ineffective(tumour
remission rate<50%)
|
n=0
n=11/17
n=3/17
n=3/17
|
KTP laser is safe and effective in the treatment of recurrent
laryngeal papilloma |
Liu et al |
D |
N/proc:22/NA
Age:3-60
years old
Gender:NA
|
Retrospective |
Laryngeal
Papilloma
|
NA |
Complications
Cure
Recuurence
|
n=2/22
n=19/22
n=3/22
|
KTP laser treatment is less destructive and it has high accuracy and
precision, also with good hemostatic effect |