3.4. Indications and Contradictions
All the studies involved in this review have explicitly reported that patients were diagnosed with LP or RRP, which was confirmed by their pathological specimens and treated with CO2 laser/KTP laser excision. On the other hand, contradictions varied from study to study. Patients treated with adjunctive therapies, such as the HPV vaccine, were excluded from this study. In addition, serious cases with systemic metastases, such as lung, were also excluded. Moreover, patients were treated with not only CO2 laser/KTP laser but also with other techniques at the same time point, such as PDL laser and microblade excision, were no involved. The age and gender were not limited to a specific scope.