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Hypothermic Circulatory Arrest Time affects neurological outcomes of Frozen Elephant Trunk for Acute Type A Aortic Dissection: a systematic review and meta-analysis
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  • Mostafa Mousavizadeh,
  • Mahdi Daliri,
  • Hadi Abo Aljadayel,
  • Mohammed Idhrees,
  • Yousef Rezaei,
  • Mohamad Bashir,
  • Saeid Hosseini
Mostafa Mousavizadeh
Rajaie Cardiovascular Medical and Research Center

Corresponding Author:[email protected]

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Mahdi Daliri
Rajaie Cardiovascular Medical and Research Center
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Hadi Abo Aljadayel
Rajaie Cardiovascular Medical and Research Center
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Mohammed Idhrees
SRM Institutes for Medical Science Vadapalani
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Yousef Rezaei
Rajaie Cardiovascular Medical and Research Center
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Mohamad Bashir
Royal Blackburn Hospital
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Saeid Hosseini
Rajaie Cardiovascular Medical and Research Center
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Background: The treatment of complex thoracic aorta pathologies remains a challenge for cardiovascular surgeons. After introducing Frozen Elephant Trunk (FET), a significant evolution of surgical techniques has been achieved. The present meta-analysis aimed to assess the efficacy of FET in acute type A aortic dissection (ATAAD) and the effect of circulatory arrest time on post-operative neurologic outcomes. Methods: A standard Preferred Reporting Items for Systematic Reviews and Meta-Analyses search was conducted for all observational studies of patients diagnosed with ATAAD undergoing total arch replacement with FET reporting in-hospital mortality, bleeding, and neurological outcomes. A random-effect meta-analysis was performed using STATA software (StataCorp, TX, USA). Results: Thirty-five studies were eligible for the present meta-analysis, including 3211 patients with ATAAD who underwent total arch replacement with FET. The pooled estimate for in-hospital mortality, postoperative stroke, and spinal cord injury were 7% (95% CI 5 – 9; I2 = 68.65%), 5% (95% CI 4 – 7; I2 = 63.93%), and 3% (95% CI 2 – 4; I2 = 19.56%), respectively. Univariate meta-regression revealed that with increasing the duration of hypothermic circulatory arrest time, the effect sizes for postoperative stroke and SCI enhances. Conclusions: It seems that employing the FET procedure for acute type A dissection is associated with acceptable neurologic outcomes and a similar mortality rate comparing with other aorta pathologies. Besides, increasing hypothermic circulation arrest time appears to be a significant predictor of adverse neurologic outcomes after FET.
26 Apr 2021Submitted to Journal of Cardiac Surgery
27 Apr 2021Submission Checks Completed
27 Apr 2021Assigned to Editor
27 Apr 2021Reviewer(s) Assigned
04 May 2021Review(s) Completed, Editorial Evaluation Pending
04 May 2021Editorial Decision: Accept
Sep 2021Published in Journal of Cardiac Surgery volume 36 issue 9 on pages 3337-3351. 10.1111/jocs.15700