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Comment on “ACE inhibitors and COVID-19: We don’t know yet”
  • Tevfik Ilcol,
  • Erkan Cure,
  • medine cumhur cure
Tevfik Ilcol
Ota&jinemed hospital

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Erkan Cure
Ota&jinemed hospital
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medine cumhur cure
Private practise
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We read with great interest the article by Khashkhusha TR et al “ACE inhibitors and COVID-19: We don’t know yet”. The authors discuss whether the use of angiotensin-converting enzyme (ACE) inhibitors (ACEIs) in novel coronavirus disease‐19 (COVID‐19) patients is beneficial or harmful. ACEIs and angiotensin receptor antagonists (ARBs) both upregulate ACE2 levels. We believe that ARBs should be preferred since, unlike ARBs, ACEIs may increase angiotensin II through the chymase pathway. We would like to discuss potential harms ACEI may cause through secondary bradykinin-chymase pathways.
01 May 2020Submitted to Journal of Cardiac Surgery
02 May 2020Submission Checks Completed
02 May 2020Assigned to Editor
02 May 2020Review(s) Completed, Editorial Evaluation Pending
02 May 2020Editorial Decision: Accept
Published in Cardiac Surgery volume 35 issue 6 on page 1387. Jun 2020. 10.1111/jocs.14647