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Evaluation of the prognostic value of lymphadenectomy in low-grade serous ovarian cancer: A case-control multicenter retrospective study
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  • Zhongshao Chen,
  • Ran Chu,
  • yuanming Shen,
  • Qin Yao,
  • Tianyu Qin,
  • Li LI,
  • Gang Chen,
  • Chaoyang Sun,
  • Li Song,
  • Junting Li,
  • Penglin Liu,
  • Xiyu Pan,
  • Jingnan Li,
  • Xiaoying Zhu,
  • Li Zhang,
  • Beihua Kong,
  • Kun Song
Zhongshao Chen
Shandong University Cheeloo College of Medicine
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Ran Chu
Shandong University Cheeloo College of Medicine
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yuanming Shen
Women's Hospital School of Medicine Zhejiang University
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Qin Yao
The Affiliated Hospital of Qingdao University
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Tianyu Qin
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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Li LI
Shandong University Qilu Hospital
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Gang Chen
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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Chaoyang Sun
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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Li Song
Shandong University Qilu Hospital
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Junting Li
Shandong University Cheeloo College of Medicine
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Penglin Liu
Shandong University Cheeloo College of Medicine
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Xiyu Pan
Shandong University Cheeloo College of Medicine
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Jingnan Li
Women's Hospital School of Medicine Zhejiang University
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Xiaoying Zhu
The Affiliated Hospital of Qingdao University
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Li Zhang
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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Beihua Kong
Shandong University Qilu Hospital
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Kun Song
Shandong University Qilu Hospital

Corresponding Author:[email protected]

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Abstract

ABSTRACT Objective: To evaluate the effect of lymphadenectomy on clinical outcome in patients with low-grade serous ovarian cancer (LGSOC). Design: Case-control multicenter retrospective study. Setting: University Hospital-based research center. Population: 147 patients with LGSOC. Methods: Propensity score matching (PSM) algorithm was used to balance the basic characteristics of patients with lymphadenectomy or not, and the Kaplan-Meier analysis was used to evaluate the impact of clinical prognosis. Finally, univariate and multivariate Cox proportional hazards regression analysis were performed to analyze the high-risk factors associated with clinical prognosis. Main outcome measures: Disease-free survival (DFS) and overall survival (OS). Results: A total of 147 women from 4 medical centers were enrolled. In the before matching cohort, 101 (68.7%) patients underwent lymphadenectomy. Fifty-two (35.4%) patients experienced recurrence, and 25 (17%) patients died. Kaplan-Meier analysis showed that there was no significant difference in DFS(P=0.058) and OS(P=0.067) in the after matching cohort. Cox proportional hazard regression analysis showed age (P=0.012), the International Federation of Gynecology and Obstetrics (FIGO) stage (P=0.031) and effective cytoreductive surgery (P=0.044) were 3 high-risk factors associated with recurrence. Age (P=0.031) and effective cytoreductive surgery (P=0.009) were 2 high-risk factors associated with death. Conclusions: Lymphadenectomy seems not to provide a significant benefit neither DFS nor OS in our study. Age, the FIGO stage and effective cytoreductive surgery are high-risk factors associated with clinical prognosis in LGSOC patients.