Faropenem, a stable and orally bioavailable β-lactam, to counteract
resistant pathogens and infectious diseases. A narrative review
Abstract
Antimicrobial resistance is a huge challenge for the effective
prevention and treatment of infectious diseases worldwide.
Community-onset infections with Extended-spectrum β-lactamases (ESBL)
producing bacteria are a challenge. In various studies, ESBL-producing
isolates were consistently susceptible only to carbapenems. When
treatment with other antibiotics fails, carbapenems are used as the
last-line antibiotics for treating severe and/or resistant bacterial
infections. In this narrative review, we aim to present the pharmacology
of Faropenem, which is an orally administered penem antibiotic with a
broad-spectrum activity against many Gram-positive and Gram-negative
aerobes, and anaerobes. Faropenem is effective in the treatment of
uncomplicated cystitis and is a potential solution to combat the
emergence of resistance among respiratory tract pathogens. It is an
alternative to fluoroquinolones or macrolides/ketolides when there is a
concern with resistant pathogens. Keywords: β-lactamases, Carbapenems,
Faropenem.