Parkinson’s psychosis refers to psychotic symptoms such as illusions, hallucinations, and delusions that are frequently referred to as ‘positive,’ meaning a benefit. Quetiapine was the most commonly used initial atypical antipsychotic medicine for therapy, followed by Risperidone, Olanzapine, Aripiprazole, and other atypical antipsychotics. According to new research, Pimavanserin may surpass other therapy for older people with Parkinson’s disease (PD) psychosis. Pimavanserin is a powerful inverse agonist with a preference for 5-HT2A receptors over 5-HT2C receptors and no functional activity at a number of G-Protein coupled receptors GPRCs such as dopaminergic, muscarinic, adrenergic, and histaminergic receptors. Pimavanserin had a relative protective effect in 85 percent of the study group of PD patients living in the community.
Rosuvastatin is a lipid-lowering medication that is routinely used to reduce blood cholesterol levels. It acts by inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol production, preventing de novo cholesterol synthesis and increasing the amount of low-density lipoprotein (LDL) receptors on the liver surface, resulting in lower blood LDL levels. Rosuvastatin has some adverse effects, including moderate ones like headache, stomach discomfort, nausea, and weakness, as well as major ones like muscle, liver, and renal issues including severe muscular pain, decreased appetite, dark-colored urine, and continuous nausea/vomiting. According to recent research, rosuvastatin medication can produce renal tubular toxicity in persons who have no prior history of kidney disease. Rosuvastatin has been linked to myalgia, rhabdomyolysis, and elevated creatine phosphokinase levels. If patients on rosuvastatin have muscular or renal difficulties, they should seek emergency medical assistance. Nonetheless, Rosuvastatin’s lipid-lowering effects exceed the danger of adverse effects. Strong adherence to these safety precautions can enhance Rosuvastatin’s safety profile and allow it to be given safely for hypercholesterolemia.