A CLINICAL ANALYSIS OF GLYCEMIC STATUS AND ITS DETERMINANTS AFTER
ANTENATAL CORTICOSTEROIDS
Abstract
Objective To study the patterns of glycemic status in response to
Antenatal corticosteroid administered to women with risk of preterm
delivery between 24 weeks and 36 weeks 6 days of gestation in
normoglycemic subjects and to evaluate if maternal characteristics
predicted the development of hyperglycemia Design : longitudinal study
Participants : 76 antenatal women, normoglycemic status between 24 weeks
and 36 week 6 days of gestation Methods : Antenatal women who screened
negative for Gestational Diabetes Mellitus by 75 gm GTT who received
Injection Betamethasone for risk of preterm delivery . Fasting and
Postprandial blood sugar levels were recorded from day 1 to 7 after
steroid administration. Results Forty seven out of seventy six patients
had hyperglycemia of varying severity. Among the risk factors associated
with hyperglycemia, age>25 years, family history ofdiabetes
and hypertension and BMI >25 have statistically significant
association with hyperglycemia. was Conclusion : Antenatal
corticosteroids have proven benefit in reducing neonatal mortality and
morbidity hence should be definitely administered as benefit outweigh
sideeffects .Hyperglycemia can occur even in normoglycemic women after
antenatal corticosteroids. Testing of all antenatal patients who are at
risk for development of hyperglycemia especially in age group more than
25years, BMI over 25, hypertensive patients, family history of diabetes
is recommended after ACS . KEY WORDS : GLYCEMIC STATUS, ANTENATAL
STEROIDS