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New protocol for pathological diagnosis and treatment pathway based on the “BIOCO” collector tool in Henan Cancer Hospital
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  • Wenqun Xing,
  • Wenjia Tian,
  • Bing wei,
  • Jiani Yuan,
  • Lingyue Xing,
  • Chengzhi Zhao,
  • Yuxi Chang,
  • Haibo Sun,
  • Rui Sun,
  • Zhongxian Zhang,
  • Yang Yu,
  • Jie Ma
Wenqun Xing

Corresponding Author:[email protected]

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Wenjia Tian
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Jiani Yuan
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Lingyue Xing
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Chengzhi Zhao
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Yuxi Chang
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Zhongxian Zhang
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Abstract

Background. 2018 Guideline from the College of American Pathologists(CAP), the International Association for the Study of Lung Cancer (IASLC) , and the Association for Molecular Pathology(AMP) established a benchmark turnaround time (TAT), according to which the results were supposed to be available to the treating oncologist within 10 working days. Methods. In this study, we established and validated a new protocol for pathological diagnosis and treatment pathway that was tested in the Henan Cancer Hospital, China. Results. Compared with the routine pathway, the new path adopts a parallel approach to conventional pathology and molecular pathology, which significantly shortens the TAT to 4-6 days. Self-designed DNA biology collector “BIOCO” tool, designed by our team to collect specimens that are discarded when the wax block is trimmed, can effectively save pathological samples, avoid cross-contamination and reduce the period extension caused by re-sampling. Most importantly, its accuracy and effectiveness are consistent with conventional collection methods. Conclusions. Therefore, the new diagnosis and treatment pathway based on the BIOCO collector can be used as a practical approach to the molecular diagnostic platform of the hospital pathology department.
09 Jul 2020Submitted to Biotechnology Journal
12 Jul 2020Submission Checks Completed
12 Jul 2020Assigned to Editor