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Saravanakumar Venkatachalam
Vellakovil
Public Documents
1
Prediction and possible molecular interactive role of wild type and HGPS mutant lamin...
Niranjan Chellathurai Vasantha#
and 6 more
May 27, 2020
Lamins are intermediate filament protein located in the inner nuclear membrane, which maintains the structural integrity and function of the nucleus. we have examined the possible interactive role of wild as well as mutant type lamin A in connection with telomere repeat binding protein trf2. Briefly, bioinformatic prediction shows that lamin A has strong interaction with telomeric complexes. DNA binding assay confirms the strong interaction between wild type lamin A and telomeric DNA sequences. Loss of 39 amino acids at C-terminal end of lamin A impairs the nuclear structural integrity and induce chromosomal fusion. We conclude that C-terminal 39 amino acids from tail domain of mature lamin A possibly interact with trf2 and telomere, not lamin C and HGPS mutant lamin A.