Based on the pandemic of COVID-19 in 2020, to avoid crowds and mass infection, web-based learning takes the place of traditional class teaching to become the main learning method for adults, teachers, and students, the study aims to check the relationship between web-based learning tools, self-efficacy, depression-anxiety-stress, family life quality, and general health in Chinese sample. Through a questionnaire and measurement scale to collect data in June to July 2020, adopted SPSS 25.0 and Mplus 8.3 to test the reliability and validity, structural equation modeling (SEM), multiple regression model (MRM), and other methods are used for statistical analysis and conclusions.