Study Objective: The purpose of this study was to determine the effects of self-prone positioning on oxygenation in COVID-19 positive patients utilizing supplemental oxygen and incidence of intubation. Method: A one-year observational cohort pilot study at a major inner-city hospital to evaluate self-proning on independent COVID-19 positive patients. Qualified patients 18 years of age or older were recruited based on inclusion and exclusion criteria. Data collection included vital signs and timing for body position changes, and results were analyzed using descriptive and inferential statistics. Results: Between April 2020 and May 2021, 93 COVID-19 enrolled patients engaged in stomach or lateral self-prone positioning. Eighty-four percent (n=78) of the population did not require intubation, whereas 16% (n=15) were intubated during their hospital stay. SpO2 means were determined for each population and prone position: Non-intubated (stomach) - before proning 93% (IQR 4) and during proning 95% (IQR 3); (lateral) before proning 92% (IQR 4) and during proning 93% (IQR 4). Intubated (stomach) - before proning 90% (IQR 7) and during proning 95% (IQR 4); (lateral) before proning 92% (IQR 5) and during proning 95% (IQR 5). Stomach proning significantly increased oxygenation in the non-intubated (p <0.001) and intubated (p 0.017) populations. Lateral proning significantly improved oxygenation in the intubated population (p 0.002). Conclusion: Self-proning in the independent COVID-19 positive patient on supplemental oxygen was effective in improving SpO2 levels short-term. Further controlled trial studies will elucidate the duration of proning effects and reinforce its use as a noninvasive rescue intervention to prevent intubation.