Abstract

With obesity becoming an epidemic, adipocytes have attracted widespread attention. Growing studies have shown that the function of adipocytes is far more than storing energy. As endocrine organs, adipocytes play a pivotal role in the occurrence and prevention of many diseases. Especially it can secrete cytokines and mediate chronic inflammation, making it one of the assistants of tumor development. Breast cancer is the main cause of cancer death in women, and its development has experienced proliferation, invasion, migration, metastasis, and drug resistance. It reports that the mammary gland is rich in adipocytes. And adipocytes can communicate with breast cancer cells and play a pivotal role in breast cancer development. It displays that adipocytes promote the proliferation, metastasis, and drug resistance of breast cancer. This suggests that focusing on adipocytes may be helpful for tumor treatment. In this paper, we reviewed the regulation mechanism of adipocytes on the development of breast cancer and proposed strategies to treat breast cancer. And this may provide a research basis for the prevention and treatment of breast cancer.