OUTCOMES OF INDUCTION VERSUS SPONTANEOUS ONSET OF LABOUR WHEN PERFORMED
AT 40 AND 41 GESTATIONAL WEEKS: FINDINGS FROM A PROSPECTIVE INDIVIDUAL
PATIENT DATABASE IN SRI LANKA
Abstract
Objectives The World Health Organization (WHO) recommends induction of
labour (IOL) for low risk pregnancy from 41+0 gestational weeks (GW).
Nevertheless, in Sri Lanka IOL at 40 GW is common practice. This study
aimed to compare maternal/newborn outcomes after IOL versus spontaneous
onset of labour (SOL) at 40 GW (IOL40) and 41 GW (IOL41). Design
Observational study. Setting De Soysa Teaching Hospital for Women,
Colombo, the largest maternity hospital in Sri Lanka. Population Low
risk pregnancies at 40 or 41 GW. Methods Data from a routine prospective
individual patient database were analysed. IOL and SOL groups were
compared using logistic regression. Main Outcome Measures Births with
one or more negative maternal/newborn outcome/s; maternal/newborn
complications; caesarean section (CS); operative vaginal delivery.
Results Of 13670 deliveries, 2359 (17.4%) were singleton and low risk
at 40 or 41 GW. Of these, 456 (19.3%) women underwent IOL40, 318
(13.5%) IOL41, and 1585 (67.2%) SOL. Both IOL40 and IOL41 were
associated with an increased risk of any maternal/newborn negative
outcomes (OR=2.21, 95%CI=1.75-2.77, p<0.001 and OR=1.91,
95%CI=1.47-2.48, p<0.001 respectively), maternal
complications (OR=2.18, 95%CI=1.71-2.77, p<0.001 and OR=2.34,
95%CI=1.78-3.07, p<0.001 respectively) and CS (OR=2.75,
95%CI=2.07-3.65, p<0.001 and OR=3.01, 95%CI=2.21-4.12,
p<0.001 respectively). Results did not change in secondary and
sensitivity analyses. Conclusions Both IOL groups were associated with
higher risk of negative outcomes compared to SOL. These findings, though
potentially explained by selection bias, local IOL protocols and CS
practices, are valuable for the Sri Lankan context, particularly given
contradictory findings from other settings.