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The effect of oral probiotics on CD4 count in patients with HIV infection undergoing treatment with ART who have had immunological failure
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  • Masoud Mortezazadeh,
  • Saeed kalantari,
  • Nooshin Abolghasemi,
  • Mitra Ranjbar ,
  • Saeedeh Ebrahimi,
  • Abbas Mofidi,
  • Babak pezeshkpour,
  • Ensieh Sadat Mansouri,
  • seyed zia tabatabaei,
  • MEHDI KASHANI
Masoud Mortezazadeh
Tehran University of Medical Sciences

Corresponding Author:[email protected]

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Saeed kalantari
Iran University of Medical Sciences
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Nooshin Abolghasemi
Islamic Azad University
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Mitra Ranjbar
Iran University of Medical Sciences
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Saeedeh Ebrahimi
Alborz University of Medical Sciences
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Abbas Mofidi
Iran University of Medical Sciences
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Babak pezeshkpour
Iran University of Medical Sciences
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Ensieh Sadat Mansouri
Tehran University of Medical Sciences
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seyed zia tabatabaei
Tehran University of Medical Sciences
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MEHDI KASHANI
Tehran University of Medical Sciences
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Abstract

Introduction: Probiotics are live microorganisms that, when administered in appropriate colonies, can delay the destruction of the immune system and contribute to the maintenance of immunity in HIV patients. Probiotics play an important role in stimulating natural killer T cells, strengthening the functional gut barrier, and reducing systemic inflammation. Methods: This study was a randomized double blind clinical trial involving 30 patients treated with ART who had experienced immunological failure despite HIV viral suppression. Patients were divided into two equal groups of 15, the first group received 2 probiotic capsules daily with a colony count of 10⁹CFU per capsule containing seven strains ,after three months they were examined for CD4+ counts by flow cytometry, after a one month washout period the participants who had received probiotics were switched to placebo, and the participants who had received placebo were given probiotics for three months, and they were examined for CD4+ counts seven months after the start of the study. Results: In the first group, administration of the placebo resulted in a decrease in CD4 count in the first three months (from 202.21 to 181.79, p-value < 0.001),which may be due to the natural history of the disease. After probiotics administration, CD4 count increased significantly (from 181.79 to 243.86, p-value < 0.001). Overall, after 7 months of study, there was a significant increase in the mean CD count from 202.21 to 243.86 (p-value < 0.001). In the second group, administration of probiotics in the first three months of the study resulted in a significant increase in the mean CD4 count (from 126.45 to 175.73, p-value < 0.001).Termination of treatment with probiotics resulted in a significant decrease (from 175.73 to 138.9, p-value < 0.001)but overall the CD4 count at the end of the study was significantly higher than at baseline (p-value < 0.001).
29 Nov 2022Submitted to Immunity, Inflammation and Disease
10 Dec 2022Submission Checks Completed
10 Dec 2022Assigned to Editor
13 Dec 2022Review(s) Completed, Editorial Evaluation Pending
23 Dec 2022Reviewer(s) Assigned
08 Jan 2023Editorial Decision: Revise Major
09 Jan 20231st Revision Received
11 Jan 2023Submission Checks Completed
11 Jan 2023Assigned to Editor
11 Jan 2023Review(s) Completed, Editorial Evaluation Pending
11 Jan 2023Reviewer(s) Assigned
27 Apr 2023Editorial Decision: Revise Major
15 May 20232nd Revision Received
16 May 2023Submission Checks Completed
16 May 2023Assigned to Editor
16 May 2023Review(s) Completed, Editorial Evaluation Pending
16 May 2023Reviewer(s) Assigned
24 May 2023Editorial Decision: Revise Minor
28 May 20233rd Revision Received
29 May 2023Submission Checks Completed
29 May 2023Assigned to Editor
29 May 2023Review(s) Completed, Editorial Evaluation Pending
29 May 2023Reviewer(s) Assigned
30 May 2023Editorial Decision: Accept
Jun 2023Published in Immunity, Inflammation and Disease volume 11 issue 6. https://doi.org/10.1002/iid3.913