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Human Papillomaviruses - known knowns, known unknowns, and unknown unknowns!
  • K Munger,
  • Maya K. Gelbard
K Munger
Tufts University School of Medicine

Corresponding Author:[email protected]

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Maya K. Gelbard
Tufts University School of Medicine
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Abstract

There has been an explosion in the number of papillomaviruses that have been identified and fully sequenced. Yet only a minute fraction of these has been studied in any detail. Most of our research efforts have focused on the E6 and E7 proteins of “high-risk”, cancer-associated human papillomaviruses (HPVs). Interactions of the high-risk HPV E6 and E7 proteins with cellular targets, the p53 and the retinoblastoma tumor suppressors have been investigated in minute detail. Some have thus questioned if research on papillomaviruses remains an exciting and worthwhile area of investigation. However, fundamentally new insights on the biological activities and cellular targets of the high-risk HPV E6 and E7 proteins have been discovered and previously unstudied HPVs have been associated with human diseases. HPV infections continue to be an important cause of human morbidity and mortality and since there are no antivirals to combat HPV infections, research on HPVs should remain attractive to new investigators and biomedical funding agencies, alike.
26 Aug 2023Submitted to Journal of Medical Virology
28 Aug 2023Submission Checks Completed
28 Aug 2023Assigned to Editor
28 Aug 2023Review(s) Completed, Editorial Evaluation Pending
28 Aug 2023Reviewer(s) Assigned
20 Sep 2023Editorial Decision: Revise Minor
08 Oct 20231st Revision Received
10 Oct 2023Submission Checks Completed
10 Oct 2023Assigned to Editor
10 Oct 2023Review(s) Completed, Editorial Evaluation Pending