A Study on the Association between Human Papillomavirus Infection,
Vaginal Microecological Imbalance, and Cervical Lesions in Women from
Xinjiang, China
Abstract
This study analyzes the relationship between Human Papillomavirus (HPV)
infection, vaginal microecological, and cervical lesions to provide a
basis for the prevention and treatment of cervical cancer (CC) in the
Xinjiang region. qRT-PCR was used for HPV genotyping and viral load.The
Gram staining and dry biochemical enzyme kit were utilized to diagnose
vaginal secretions.The positive rate of HPV infection and vaginal
microecological indicators was compare by χ 2 test.
Logistic regression analysis was used to analyze the correlation between
vaginal microecological evaluation indicators and HPV infection with the
grade of cervical lesions. The HPV infection rate among women in the
Xinjiang region is 30.29%, of which single HPV infection accounts for
77%. HPV16 and HPV52 are the main infection types. There are
significant differences in the HPV infection rate and infection types
among the Han, Uighur, Hui, and Kazakh ethnic groups. The viral load of
HPV16 and HPV52 increases with the upgrade of cervical lesions. There
are significant differences in vaginal microecological evaluation
indicators H 2O 2, SNA, LE, GUS,
trichomonas, clue cells, and lactobacilli among different ethnic groups.
HPV negative patients with varying grades of cervical lesions exhibit a
notable variance in H 2O 2 and LE, which
is statistically significant. single HPV infection and high viral load
HPV significantly increase the risk of CC. This study indicate that the
HPV infection and vaginal microecological are differences among ethnic
groups, Which have a strong correlation with the progression of CC,
Offering guidance on CC screening and interventions in the Xinjiang
area.