This cross-sectional study examined COVID-19 attitudes and vaccine hesitancy among African American and Nigerian college students ( N = 189). African American and Nigerian college students were sampled from regional universities within the United States and Nigeria. Participants completed the World Health Organization (WHO) Vaccine Hesitancy Scale (VHS; 2014) and sociodemographic questions to assess attitudes, primarily vaccination hesitancy, toward COVID-19 vaccination. Independent t tests revealed no significant differences between the nationalities and any hesitancy in taking the COVID-19 vaccine ( t(167) = .334, p = .739). However, there was a significant effect for trust in the COVID-19 vaccine ( t(174) = -3.42, p = <.001), with American students ( M = 0.59; SD = 0.50) showing more trust than Nigerian students ( M = 0.34; SD = 0.48). In addition, there was a significant effect for the overall general support of vaccines, t(176) = 2.43 p = .016, with Nigerian students ( M = 0.86; SD = 0.35) showing more favor than American students ( M = 0.71; SD = 0.46). Additional analyses associated with the cross-cultural comparisons were conducted and discussed.