Introduction: Telemedicine and tele-monitoring represent an emerging-study area in several and chronic diseases. Tele-rehabilitation during Covid-19 disease became an essential tool to promote physical activity in total safety. Infact, for pwCF physical activity was fundamental not only for the respiratory program but also Aim: To evaluate the feasibility of home web-based program of home exercise training program in patients with cystic fibrosis during COVID-19 pandemic. Subjects and methods: 32 patients (12 M/ 20 F) age 20,52 (±9,3); FEV1 mean was 84,88% and Ph angle mean at T0 was 6,11 (sd 0,83). Results: Adherence average rate was 61,5 %. Satisfaction and utility scores were respectively 4.5 and 4.3(Likert Scale); about QoL the Body-domain had a statistically significant increase (pvalue <0.05). Conclusion: Web-based rehabilitation could be a good tool but more studies are needed to confirm optimal values of adherence. Although data are based on a small sample size and longer periods of treatment are requested to analyze especially the physiological answer about heart rate and lung volumes.