Lower sFlt-1/PlGF Ratio in Positive Prediction of Preeclampsia for Women
with Hypertension in Pregnancy
Abstract
Objective To evaluate the optimal Kryptor threshold for sFlt-1/PlGF on
PE among the hypertensive pregnant women. Design A single centre
prospective study. Setting Guangzhou Women and Children’s Medical Care
Center. Population or Sample 565 singleton pregnant women with
hypertension from January 2018 to June 2021. Methods PlGF/sFlt-1 and
perinatal data were collected and logistic regression was used to
explore the cutoffs of sFlt-1/PlGF for PE from different hypertension
types in HDP. Main outcome measures PlGF/sFlt-1 cutoff of PE and chrHBP
with PE in HDP . Results: The sFlt-1 /PlGF ratio in PE and chrHBP with
PE were significantly higher than GH & chrHBP, in which early-onset
were higher. For gestatioanl hypertension, sFlt-1 /PlGF
ratio> 36.44 could rule in PE occurence(AUC=76.17% -
78.39%) in 1-4week with PPV 0.91-0.94 & NPV 0.67 before 34 weeks,
while sFlt-1 /PlGF ratio< 51.52 could rule out PE occurrence
(AUC=75.29% - 78.39%) in 1-4 weeks with NPV 0.91-0.96 & PPV 0.62-0.73
after 34 weeks. For chronic hypertension, sFlt-1 /PlGF
ratio> 47.78 could rule in PE occurrence (AUC=82.5% -
86.36%) in 1-4 weeks with PPV 0.9-0.96 & NPV 1.0 before 34 weeks,
while sFlt-1 /PlGF ratio< 28.61 could rule out PE
occurence(AUC=72.41% - 73.03%) in 1-4 weeks with NPV 0.88 & PPV
0.43-0.79 after 34 weeks. Conclusion: Lower sFlt-1/PlGF had high
positive potential to identify the patients to develop early onset PE
from gestational and chronic hypertension, which could complement the
strategy to hypertensive disorders in pregnany. Funinding Guangzhou
science and technology Program Project (202102010163) .