Efficacy of Bisphosphonates and Recombinant Parathyroid Hormone in
Treatment of Osteoporosis in Pakistan
Abstract
Background; Osteoporosis is one of such disease which causes bone mass
reduction by decreased formation of new bones. Low bone mineral density
is frequent factor for osteoporosis. Increased osteoclast life span and
advanced osteocytes as well as osteoblasts apoptosis is well adopted
pathophysiological mechanism for low bone mass. Women are more prone
than man. Approximately 200 million women have osteoporosis worldwide.
Objective; Therefore, this study is designed to compare efficacy of
bisphosphonates and recombinant human Para-thyroid hormone in treatment
of osteoporosis. Main outcome measures; The comparison of these two
treatment strategies is based upon therapeutic effectiveness, cost of
therapy and availability of the drugs. Methods; The total duration of
study was 1 year and during the study period a total 60 samples were
analyzed randomly. Data was collected using a well-designed
questionnaire. Results; rhPTH increase bone mass density (BMD) by 8-9%
while bisphosphonates and estrogen therapy increase BMD 3-5% during the
same time period. Conclusion; The current study was conducted in local
population so that we could offer them the test possible treatment among
the two most common treatment therapies available for osteoporosis.