This work advances the cross-model deployment of ecological and biogeochemical simulation capabilities in existing process-based hydro-modeling tools, which we term “Open Water Quality” (OpenWQ). The companion paper details aspects of the OpenWQ architecture that enables its plug-in type incorporation into existing models, along with its innovative aspects that enable biogeochemistry lab-like capabilities. OpenWQ’s innovative aspects allow modelers to define the pollution problem(s) of interest, the appropriate complexity of the biogeochemistry routines, test different modeling hypotheses, and deploy them across different hydro-models. In this second paper, we implemented the coupling recipe described in the first paper to integrate OpenWQ into two hydro-models, SUMMA and CRHM. Here we explain how the implemented coupling interface between the two models provides water quality simulation capacities in the host hydro-models but, more importantly, establishes a direct and permanent link for the transfer of innovation between the modeling communities. Example applications of different pollution studies enabled by our coupling recipe are also provided to address some of these fundamental water quality modeling challenges.