South China(SC) is characterized by large-area multistage magmatism.There are five large-scale metallogenic belts in SC, multiple world-class deposits have been discovered, showing great prospecting potential. What led to the difference in the type and metal association of the deposits? What controls the distribution of the different types of metallogenic belts? Where can we find new deposits? To address these concerns, it is necessary to consider the metallogenic factors based on mineral system. Firstly,the satellite gravity was converted into Bouguer gravity under spherical coordinates. Then the reduction-to-the pole (RTP) magnetic anomalies in SC were obtained using the moving window with different geomagnetic parameter respectively.Further to that, inversion of gravity and magnetic data was applied to calculate the vertical lithospheric interfaces,and then the possible metallogenic source zones of the five metallogenic belts were analyzed. The distribution of main faults were determined and the boundaries among Yangtze Block (YB), Cathaysia Block (CB) and Jiangnan Orogenic belt (JNO) were redefined by multiscale edge detection of gravity and magnetic data,then the ore-forming pathways in the main metallogenic belts were explored. 3D spatial distribution of intrusions qualitatively identified by inverted susceptibility and density model , and hence the depositing site of Cu, Fe, Au, W and Sn deposits were inferred. The metallogenic source zones, pathways, and sites of the deposits of the mineral system in SC were qualitatively identified according to the gravity and magnetic data analysis , providing indications for future prospecting exploration in SC.