Results and Conclusion
The uptake of 1 in HCT116AF vs HCT116WT cells was 3.5-fold higher and could be blocked by preincubation with nonradioactive 1.
The uptake of 1 in AF over-expressing tumors was higher than in the controls (3.1±0.7 (n=5) vs. 1.2±0.7 (n = 5) %ID/cc). Preliminary preclinical study revealed tracer uptake in arthritic ankles to be 2.3-fold higher than the control.