Authors: Jonathan Cotton, Simon Freisinger, Kerstin Fuchs, Christoph Goering, Andreas Maurer, Nicolas Beziere, Bernd J. Pichler
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tuebingen, Germany
Background
α-Fucosidase (AF) is implicated in many pathologies e.g. cancer, senescence and inflammatory processes such as arthritis. The pyrrolidine 4-epi-(+)-Codonopsinine 1 is an AF inhibitor (AFi) with respective IC50 and Ki values of 58 nM of 10 nM.