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\begin{document}

\title{Meet the CAFACHEM Keynote Speaker:

Prof. Peter J. H. Scott}



\author[1]{SRSTT Radiopharmaconnect}%
\affil[1]{Radiopharmaconnect}%


\vspace{-1em}



  
  \date{June 13, 2024}


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\href{https://www.srsweb.org/cafachem2020}{\textbf{CAFACHEM~2020}}
organizers are grateful for the support
of~\href{https://www.imigine.com/}{\textbf{}}\textbf{\href{https://www.pmod.com/web/}{\textbf{PMOD}}}\selectlanguage{english}
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\textbf{Position:} \emph{Associate Professor of Radiology and
Pharmacology, Director of PET Radiochemistry, Faculty Scientist in
Medicinal Chemistry, University of Michigan, USA}

\emph{Education: BSc, Loughborough University, UK}

\emph{PhD, Durham University, UK}

\emph{Post-doc, SUNY Buffalo, USA}

\emph{Post-doc, University of Michigan, USA}

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\caption{{Prof. Peter J. H. Scott
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\par\null

\textbf{What is your research goal?}

\emph{The overall goal of my research program is to enhance the use of
PET imaging in personalized medicine and drug discovery through
development of new methods for late-stage radiolabeling of diverse
bioactive molecules, and discovery of new radiotracers for diseases such
as neurodegeneration. I direct numerous ongoing research projects in
these areas that have been externally funded (e.g. NIH), including an
active collaboration with Prof. Melanie Sanford developing methodology
for the late-stage radiolabeling of challenging bioactive molecules with
high A}\textsubscript{\emph{m}} \emph{}
\textsuperscript{\emph{18}}\emph{F and}
\textsuperscript{\emph{11}}\emph{C. Over 11 years of my independent
career, I have published \textgreater{}110 papers in radiochemistry and
PET imaging that have been cited \textgreater{}3000 times. It has been
gratifying to see reactions developed by my group rapidly adopted by the
radiochemistry community and used to prepare \textgreater{}100
radiotracers for (pre)clinical PET imaging in academic and industry labs
all over the world.}

\par\null

\textbf{Briefly, what excites you about your work? What is your favorite
aspect of your research?}

\emph{I was attracted to the field of Nuclear Medicine early in my
career for a number of reasons. Firstly, PET radiochemistry is a unique
and exciting application of organic chemistry with immediate impact on
patient care -- I'm still amazed to see ``same day'' images from inside
animals and patients obtained using our molecules, and truly humbled
when witnessing first hand the impact such images have on the lives of
our patients and their families. Secondly, the translational aspect of
the work is appealing (how many chemists ever witness clinical
translation of a molecule they've invented?) and, lastly, I thoroughly
enjoy the diverse and multidisciplinary nature of the work at the
interface of the intersection of medicine, biology, chemistry, physics
and engineering.}

\par\null

\textbf{What is your vision of the future of
radiochemistry/radiopharmacy/nuclear medicine?}

\emph{It is an exciting and transformative time in the fields of Nuclear
Medicine and the Radiopharmaceutical Sciences! New radiopharmaceuticals
continue to be approved for clinical use, including new theranostics for
cancer treatment, that are transforming the lives of the patients we
diagnose and treat in our clinicals every day. Coupled with lobbying
efforts by Professional Societies and others to inform coverage policy,
significant efforts by industrial partners to develop the radiochemistry
and PET imaging suites of the future, and the expected impact of the
Internet of Things and Artificial Intelligence (AI) on our discipline,
Nuclear Medicine has been invigorated and is transforming from a
research technique to a powerful standard of care.}

\par\null

\textbf{What is your opinion on why young researchers should choose
radiochemistry as their research discipline? ~}

\emph{I'm thankful every day that I am able work in this field, as
mixing cutting edge research, leadership activities in Professional
Societies, mentoring young learners, and doing work with daily patient
impact make for an extremely rewarding career! Science has also let me
see the world and for that I am also extremely grateful. For example,
visiting Beijing to talk about my science at last year's International
Symposium on Radiopharmaceutical Sciences, and have the opportunity to
visit the Forbidden City and the Great Wall of China, was pretty
badass!}

\par\null

\textbf{Do you have encouraging advice for young researchers to succeed
in the world of science?}

\begin{itemize}
\tightlist
\item
  \emph{You can learn anything and pursue whatever career you're
  passionate about, so discover what you love and do that -- then the
  hard work required to get really good at it becomes easy!~}
\item
  \emph{Find mentors and don't be afraid to pester them with questions
  (ask me to be a mentor if you're having trouble finding one!
  pjhscott@umich.edu).~}
\item
  \emph{Learn how to network today -- no one is good at it to begin with
  but it's easier than you think to learn, and an extremely important
  skill to develop.}
\end{itemize}

\par\null

\textbf{If I were not a scientist, I would be \ldots{}}

\emph{A chef -- cooking is essentially applied organic chemistry and a
similarly intense career choice!}

~

\textbf{What is your paper that you are most proud of? Why?}

Lee SJ, Makaravage KJ, Brooks AF, Scott PJH, Sanford
MS.:\href{https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.201812701}{Cu-Mediated
Radiofluorination of (Hetero) Aromatic C--H Bonds with K18F Angew}.
Chem. Int. Ed. 58(10): 3119-3122, 2019.

\emph{Of everything we have published together, this paper is the one I
am most proud of for a number of reasons:}

\emph{i) the article reports the first example of aromatic C-H
radiofluorination (the ability to transform an aromatic C-H bond into a
C-\textsuperscript{18}F bond), which has proven one of the most
difficult transformations to accomplish in radiochemistry. David
Donnelly (PET radiochemist at BMS) and I used to talk about how we could
do aromatic C-H radiofluorination in Ashley's Pub in Ann Arbor as
post-docs in Mike Kilbourn's group in 2006, but it took 13 years for PET
radiochemistry and organometallic chemistry to become sophisticated
enough, and the hard work of a brilliant post-doc (Dr. Lee) and graduate
student (Ms. Makaravage) to accomplish it!}

\emph{ii) I have worked tirelessly to create a lab culture that is
inclusive of all people, including female colleagues and trainees. I am
therefore extremely happy that 3/5 authors of this paper are rockstar
Women in STEM, and am very proud that it was selected for a special
issue highlighting Women in Chemistry.}{}

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