4
|
2001[19]
|
Male/54
|
diarrhea, fever, and weight loss
|
multiple mucosal ulcers
|
acute and chronic inflammation, with giant cells, intranuclear, and
cytoplasmic inclusions;
acute necrotizing inflammation and CMV inclusion bodies
|
Ganciclovir (2.4 mg/kg every 8 hours for 14 days), following a second
course of ganciclovir, combined with high-dose IVIG (500 mg/kg every
other day); Foscarnet (43 mg/kg every 8 hours) was then given for 21
days, then Foscarnet was continued at 75 mg/kg every 24 hours
|
Died( recurrent colitis and colonic perforation)
|
5 |
2001[19] |
Male/59 |
epigastric pain and melena |
severe
ulcerative gastritis |
acute ulcerative gastritis with extensive
CMV-like intracellular inclusions bodies and strongly positive
CMV-immunofluorescent staining |
Ganciclovir (5 mg/kg every 12
hours) for 14 days, then Foscarnet (60 mg/kg every 8 hours) was added to
the ganciclovir for 24 days. Two doses of IVIG and 1 infusion of
CMV-immune globulin were given.
Ganciclovir was stopped after 12 weeks, after follow-up endoscopy showed
improved gastritis with no inclusions and negative CMV immuno-stain. |
Improved |
6
|
2004[12]
|
Female/64
|
watery diarrhea, abdominal distention
|
gastritis, a duodenal
polyp, and mucosal edema in duodenum
|
intracellular inclusion bodies in the epithelial cytosol that were
strongly positive to mouse anti-CMV antibody
|
ganciclovir and CMV-immune globulin
|
Improved
|
7 |
2009[15] |
Female/55 |
dysphagia, watery diarrhea, a weight loss
o, abdominal pain |
several ulcers in the descendens duodeni; edematous
swelling of the mucosa with contact vulnerability, multiple ulcers in
the rectum and sigmoid colon as part of ulcerative colitis. |
duodenitis; positive immunohistochemical reactivity against CMV protein
of the endothelium and fibroblasts |
Steroid (1 mg/kg body weight) and
immunosuppression with azathioprine (1.5 mg/kg body weight) and
mesalazine and topical therapy in the form of clysters; a 3-week therapy
with ganciclovir; then subsequent therapy with Foscarnet had to be
discontinued due to gastrointestinal side effects and was replaced with
cidofovir and CMV-specific immunoglobulins; azathioprine switched to
mycophenolate mofetil |
Improved |
8
|
2010[7]
|
Male/68
|
Watery diarrhea, reduced appetite
|
Normal
|
CMV inclusion
bodies.
|
intravenous ganciclovir 5 mg/kg 12 hourly for 2 weeks, followed by
lifelong oral maintenance with valganciclovir 900 mg daily for CMV
retinitis;
Monthly immunoglobulin infusion.
|
Improved
|
9
|
2013[5]
|
Female/80
|
watery, non-bloody diarrhea
|
left-sided colitis suggestive of ulcerative colitis
|
diffuse active chronic inflammation and atypical cells with inclusion
bodies that stained positive for CMV
|
Prednisone; intravenous ganciclovir 5 mg/kg every 12 hours for 2 weeks
for disseminated CMV infection; intravenous immunoglobulin (IVIG)
followed by monthly maintenance infusions.
|
Improved
|
10 |
2022[20] |
Undescribed /44 |
fever, weight loss of 30 kg and
chronic diarrhea |
ulcers in the sigmoid colon |
acute colitis with
cryptic apoptosis without evidence of chronicity, compatible with CMV
colitis |
ganciclovir and nitazoxanide; gamma-globulin |
Died(neurological deterioration with a refractory supraconvulsive
state) |