3 2000[18] Male/47 severe anorexia, dysphagia, and vomiting severe pan-gastritis with a normal oesophagus and duodenum granulation tissue, but no gastric epithelium, specific immunostaining for CMV was strongly positive. Intravenous immunoglobulin(0.4g/kg/month); Repeated courses of anti-CMV therapy in the form of ganciclovir, then Forscarnet, combination therapy with both, and Cidofovir. Died(sepsis)
4
2001[19]
Male/54
diarrhea, fever, and weight loss
multiple mucosal ulcers
acute and chronic inflammation, with giant cells, intranuclear, and cytoplasmic inclusions; acute necrotizing inflammation and CMV inclusion bodies
Ganciclovir (2.4 mg/kg every 8 hours for 14 days), following a second course of ganciclovir, combined with high-dose IVIG (500 mg/kg every other day); Foscarnet (43 mg/kg every 8 hours) was then given for 21 days, then Foscarnet was continued at 75 mg/kg every 24 hours
Died( recurrent colitis and colonic perforation)
5 2001[19] Male/59 epigastric pain and melena severe ulcerative gastritis acute ulcerative gastritis with extensive CMV-like intracellular inclusions bodies and strongly positive CMV-immunofluorescent staining  Ganciclovir (5 mg/kg every 12 hours) for 14 days, then Foscarnet (60 mg/kg every 8 hours) was added to the ganciclovir for 24 days. Two doses of IVIG and 1 infusion of CMV-immune globulin were given. Ganciclovir was stopped after 12 weeks, after follow-up endoscopy showed improved gastritis with no inclusions and negative CMV immuno-stain. Improved
6
2004[12]
Female/64
watery diarrhea, abdominal distention
gastritis, a duodenal polyp, and mucosal edema in duodenum
intracellular inclusion bodies in the epithelial cytosol that were strongly positive to mouse anti-CMV antibody
ganciclovir and CMV-immune globulin
Improved
7 2009[15] Female/55 dysphagia, watery diarrhea, a weight loss o, abdominal pain several ulcers in the descendens duodeni; edematous swelling of the mucosa with contact vulnerability, multiple ulcers in the rectum and sigmoid colon as part of ulcerative colitis. duodenitis; positive immunohistochemical reactivity against CMV protein of the endothelium and fibroblasts Steroid (1 mg/kg body weight) and immunosuppression with azathioprine (1.5 mg/kg body weight) and mesalazine and topical therapy in the form of clysters; a 3-week therapy with ganciclovir; then subsequent therapy with Foscarnet had to be discontinued due to gastrointestinal side effects and was replaced with cidofovir and CMV-specific immunoglobulins; azathioprine switched to mycophenolate mofetil Improved
8
2010[7]
Male/68
Watery diarrhea, reduced appetite
Normal
CMV inclusion bodies. intravenous ganciclovir 5 mg/kg 12 hourly for 2 weeks, followed by lifelong oral maintenance with valganciclovir 900 mg daily for CMV retinitis; Monthly immunoglobulin infusion.
Improved
9
2013[5]
Female/80
watery, non-bloody diarrhea
left-sided colitis suggestive of ulcerative colitis
diffuse active chronic inflammation and atypical cells with inclusion bodies that stained positive for CMV
Prednisone; intravenous ganciclovir 5 mg/kg every 12 hours for 2 weeks for disseminated CMV infection; intravenous immunoglobulin (IVIG) followed by monthly maintenance infusions.
Improved
10 2022[20] Undescribed /44 fever, weight loss of 30 kg and chronic diarrhea ulcers in the sigmoid colon acute colitis with cryptic apoptosis without evidence of chronicity, compatible with CMV colitis ganciclovir and nitazoxanide; gamma-globulin Died(neurological deterioration with a refractory supraconvulsive state)