Conclusion
It is of paramount importance for clinicians to consider the possibility
of GS when adult-onset patients present with thymoma,
hypogammaglobulinemia, and recurrent infection. Chronic diarrhea was
present in almost up to 50% of GS patients. Additionally, CMV infection
is a common opportunistic pathogen and the main cause of diarrhea. The
endoscopic manifestations of patients diagnosed with GS and CMV
gastroenteritis are also non-specific, mainly characterized by ulcers,
inflammation and edema of intestinal mucosa. Therefore, clinical
confirmation depends on biopsy results and further immunohistochemical
methods. The recognized regime suggests that ganciclovir can be used as
the initial therapy, and can be switched to Foscarnet, or combined with
both for ganciclovir resistance or symptom recurrence. Finally, it is
necessary for GS patients to undertake periodic human immunoglobulin
replacement therapy and monitor their immune status,so as to prevent and
timely identify opportunistic infection.