FIGURE LEGENDS
Figure 1. Evolution of the genomic landscape in two patients of our cohort. For each patient, we show the variant allele frequency (VAF, left Y axis) of each somatic mutation identified by clinical monitoring with the NGS Oncomine Myeloid Research Assay. Each mutation is labelled according to the left legend shown above the graphs. On the X axis we report the date of testing. Response to treatment was monitored in the BM of the patient by immunophenotype of the myeloid blasts (% blasts, right Y axis). A. Patient ID5. In panel A, we also show the percentage of donor cells in the peripheral blood (% donor PB cells, right Y axis), following allogeneic BM transplantation (post Allo-TMB). The small black arrow indicates the timing of induction chemotherapy. B. Patient ID7. The first black arrow shows the timing of induction therapy and the second of re-induction therapy. Beg., beginning.