Data Extraction
Two investigators (YZQ and CZH) independently conducted the study
selection in accordance with the inclusion and exclusion criteria above
and extracted data from the included trials. The extracted information
included first author’s name, year of publication, country, National
Clinical Trials (NCT) registry number, phase, treatment regimen, sample
size, basic patient characteristics (i.e., age, primary tumor type, HER2
expression status), efficacy outcomes (PFS, OS, ORR, DCR) and incidences
of ang grade or grade≥3 AEs. Disputes during the process were resolved
by discussion with a third investigator (WS).