Introduction
There is a growing interest in cardiac electrophysiology studies with a particular focus on cardiac ion channelopathies and sudden cardiac death (SCD) in diverse populations. Previous research studies have shown disparities in the management of arrhythmias and treatment effectiveness in various ethnic groups, including African American (AA)/Black and Asian populations, but only limited data exists for Hispanic/Latino and Indigenous groups.1-3 Moreover, health disparities that could impede the detection of these arrhythmias in these two populations have yet to be fully explored. The goal of this review is to advance our understanding of the fundamental aspects of cardiac pathophysiology and shed light on potential population-specific factors influencing susceptibility to SCD. This ultimately leads to targeted interventions and therapeutic strategies tailored to different populations at risk of cardiac arrhythmias and SCD.