Title: Icariin alleviates renal inflammation and tubulointerstitial fibrosis via Nrf2-mediated attenuation of mitochondrial damage
Nannan Ding1, Shanyue Sun2, Shuting Zhou3, Zhimei Lv1*, Rong Wang1*
1. Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
2. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
3. Department of Pathology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
*Correspondence: Zhimei Lv and Rong Wang are joint corresponding authors. E-mail: lvzhimei@email.sdu.edu.cn & wangrong_sd@126.com.
Running title: The protective mechanism of icariin in CKD