Lay summary
- Alterations in the levels of circulating metabolites specific to
patients with chronic hepatitis B (CHB) exhibiting persistently
elevated alanine aminotransferase (PeALT) levels were identified.
- ALT levels were most strongly negatively correlated with levels ofN -acetyl-l-methionine (NALM); Supplementation with
NALM alleviated hepatocyte necrosis in a CCl4-induced
mouse model of acute liver injury.
- The identified key differential metabolites may serve as potential
biomarkers and/or therapeutic targets for PeALT in patients with CHB.