Introduction:
Chronic renal failure (CRF) is associated with a variety of skin manifestations. With the introduction of hemodialysis, life expectancy extended and novel dermatological conditions are being observed as there is more time for these changes to become evident. These skin alterations incluse: xerosis, pallor, pruritus and cutaneous pigmentation . Other cutaneous manifestations include Kyrle’s disease ; pseudo-Kaposi’s sarcoma, calciphylaxis, uremic frost and purpura . The nail changes include half and half nails. Hair changes include sparse body hair. However, instances of hypopigmentation are rare. Patients with CRF are typically prescribed multiple medications, some of which may provoke cutaneous reactions. Hair color alterations can arise from various genetic, metabolic, nutritional, and acquired disorders, with certain medications capable of eliciting hair loss, stimulating hair growth, or, infrequently, causing changes in hair texture and color[1–3].
Herein, we present a case of acquired hair depigmentation in a patient with chronic renal failure undergoing hemodialysis. The onset of hair color change coincided with the initiation of heptamyl therapy and reverted following discontinuation of the medication.