Introduction:
Chronic renal failure (CRF) is associated with a variety of skin
manifestations. With the introduction of hemodialysis, life expectancy
extended and novel dermatological conditions are being observed as there
is more time for these changes to become evident. These skin alterations
incluse: xerosis, pallor, pruritus and cutaneous pigmentation . Other
cutaneous manifestations include Kyrle’s disease ; pseudo-Kaposi’s
sarcoma, calciphylaxis, uremic frost and purpura . The nail changes
include half and half nails. Hair changes include sparse body hair.
However, instances of hypopigmentation are rare. Patients with CRF are
typically prescribed multiple medications, some of which may provoke
cutaneous reactions. Hair color alterations can arise from various
genetic, metabolic, nutritional, and acquired disorders, with certain
medications capable of eliciting hair loss, stimulating hair growth, or,
infrequently, causing changes in hair texture and color[1–3].
Herein, we present a case of acquired hair depigmentation in a patient
with chronic renal failure undergoing hemodialysis. The onset of hair
color change coincided with the initiation of heptamyl therapy and
reverted following discontinuation of the medication.