A. Experimental design and timeline of the reversion experiment: c-Jun~Fra-2hep mutants with 9 months of transgene expression (off Dox at weaning) were put back on Dox, followed over time and compared to littermate controls and to un-reverted mice (sacrificed at 9 months). US: Ultrasonography. B. Liver morphology and histology in c-Jun~Fra-2hep reverted and escaper mutants compared to control. Bar = 1 cm (top) and 100mm (H&E, bottom), tumors (T) are indicated by arrows and dotted line. C. Serum AFP at end point in individual mice, reversion escapers are marked in red, controls values were comparable between the ON and OFF time points and plotted together.