Case presentation:
A 41-year-old man with known sickle cell anaemia (Hb SS) who had a history of frequent vaso-occlusive crises. In the year prior to starting treatment with crizanlizumab, the patient had three pain crises at home without visiting the emergency department, three pain crises for which he was admitted to hospital, one crisis of acute chest syndrome and recurrent episodes of stuttering priapism that occurred almost weekly, each episode lasting approximately 3-5 minutes and having a pain score of 5-6 and usually resolving spontaneously. During this time. he continued to receive folic acid 5 mg daily, hydroxyurea 1000 mg daily and an increasing requirement for narcotics, so the patient was offered to increase the dose of hydroxyurea, which he refused.