Abstract
A 17-year-old pregnant woman, with a history of Tramadol,
Methamphetamine, Pregabalin and Chloral hydrate use before and during
pregnancy, admitted with severe vaginal bleeding and uterine
contraction. An emergent cesarean delivery was performed. Multiple fetal
anomalies involving all the body systems were observed, and the fetus
passed away seven minutes later. The woman was addicted to four
psychological drugs which were Pregabalin, Chloral hydrate,
Methamphetamine, and Tramadol before and during pregnancy. Pregabalin is
considered the last treatment option for various neurological diseases
in pregnant women and more research is required to assess its safety for
pregnant women. For Chloral hydrate (CH) the literature hasn’t mentioned
any previous study about the teratogenic effect of CH on fetus due to
mother intake. With addiction to Methamphetamine, cleft palate and other
cognitive, neurological, and behavioral outcomes were observed in many
studies. Cardiovascular, gastrointestinal, musculoskeletal and many
congenital deformities have been detected among women with tramadol use.
To our knowledge, this is the first case that deals with multi-drug use
during pregnancy since previous cases were only about one drug.
More research on addiction to more than one of these drugs is desirable
to extend our knowledge about their common impact on both the pregnant
woman and her fetus.