Figure 5. Crystal structure of adenovirus FArdV1
Pre-pVII NLSd bound to IMPα2ΔIBB. Protein crystals of IMPα2ΔIBB in
complex with FrAdV1 Pre-pVII NLSd FITC-labelled peptide were formed
after 3 days of incubation at 23 0C with 0.65M Na
Citrate, pH 6.5. The structure solved at 2.2 Å resolution showed the
FAdV1 pVII NLSd (shown in green color stick mode) bound to IMPα (shown
in grey surface mode) at the major binding site. The P2 binding pocket
(pink surface) is comprised of Gly150, Thr155 and
Asp192.