Fig.6: GSVA showed significant correlation between inflammatory
neutrophils and measures of disease severity.
RNAseq data from MHV-1 and mock-infected lean and obese C3H/HeJ mice was
analyzed by GSVA using immune cell (A) and inflammatory and cellular
pathway (B) gene signatures.
Linear regression analysis between inflammatory neutrophil GSVA scores
and weight loss (C), lung histopathology (D) and liver histopathology
(E). Linear regression analysis between activated B cell GSVA scores and
weight loss (F), lung histopathology (G) and liver histopathology (H).
The correlation for each comparison is displayed as the
r2 value and the significance of the correlation is
displayed as the p-value. Statistical and regression analysis was done
using GraphPad Prism. The level of significance is represented as
follows: p < 0.05 (*); p < 0.001 (**); p = 0.001 to
0.0001 (***); p < 0.0001 (****). The error bars indicate SD of
the mean.