Author contributions
Q.Q.Z., J. S. and X. J. W. designed the study. X.Y.Y., J.F.L., Y.Z.W,
M.M.L. and K.C. performed the experiments. X.Y.Y. and Q.Q.Z.wrote the
manuscript. X. J. W. supervised the overall study. J. S. is the
guarantor of this work; as such, Q.Q.Z.had full access to all the data
in the study and takes responsibility for the integrity of the data and
the accuracy of the analysis.