Introduction
Li Fraumeni syndrome (LFS) is characterized by TP53 mutations and
increases susceptibility to tumors, such as sarcoma, breast cancer,
brain tumors, and adrenocortical tumor (ACT)1.
Neuroblastoma (NB) is the most common malignancy of the adrenal medulla
in infants and is notably associated with the MYCN gene amplification.
Composite malignancy in adrenal glands or other organs is extremely rare
and usually seen in adults; only a weak association between LFS and NB
has been reported.2,3 Simultaneous ACT and NB has only
been reported in six other cases, all with varying TP53 mutations.