References
1. Campagnolo AM, Priston J, Thoen RH, Medeiros T, Assuncao AR. Laryngopharyngeal reflux: diagnosis, treatment, and latest research.Int Arch Otorhinolaryngol. 2014;18(2):184-191.
2. Gelardi M, Ciprandi G. Focus on gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR): new pragmatic insights in clinical practice. J Biol Regul Homeost Agents. 2018;32(1 Suppl. 2):41-47.
3. Kim SI, Kwon OE, Na SY, Lee YC, Park JM, Eun YG. Association between 24-hour combined multichannel intraluminal impedance-pH monitoring and symptoms or quality of life in patients with laryngopharyngeal reflux.Clin Otolaryngol. 2017;42(3):584-591.
4. Salihefendic N, Zildzic M, Cabric E. Laryngopharyngeal Reflux Disease - LPRD. Med Arch. 2017;71(3):215-218.
5. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus G. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol.2006;101(8):1900-1920; quiz 1943.
6. Lee YC, Jung AR, Kwon OE, Kang JW, Huh JH, Eun Y-G. The effect of baclofen combined with a proton pump inhibitor in patients with refractory laryngopharyngeal reflux: A prospective, open‐label study in thirty‐two patients. Clinical Otolaryngology. 2019;44(3):431-434 %U https://onlinelibrary.wiley.com/doi/abs/410.1111/coa.13297.
7. Holloway RH, Hongo M, Berger K, McCallum RW. Gastric distention: a mechanism for postprandial gastroesophageal reflux.Gastroenterology. 1985;89(4):779-784.
8. van Wijk MP, Blackshaw LA, Dent J, Benninga MA, Davidson GP, Omari TI. Distension of the esophagogastric junction augments triggering of transient lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol. 2011;301(4):G713-718.
9. Li S, Shi S, Chen F, Lin J. The effects of baclofen for the treatment of gastroesophageal reflux disease: a meta-analysis of randomized controlled trials. Gastroenterol Res Pract. 2014;2014:307805.
10. Lechien JR, Bobin F, Dapri G, et al. Hypopharyngeal-Esophageal Impedance-pH Monitoring Profiles of Laryngopharyngeal Reflux Patients.The Laryngoscope. 2021;131(2):268-276 %U https://onlinelibrary.wiley.com/doi/210.1002/lary.28736.
11. Kim SI, Jeong SJ, Kwon OE, et al. Pharyngeal reflux episodes in patients with suspected laryngopharyngeal reflux versus healthy subjects: a prospective cohort study. Eur Arch Otorhinolaryngol.2021.
12. Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16(2):274-277.
13. Hoppo T, Sanz AF, Nason KS, et al. How much pharyngeal exposure is ”normal”? Normative data for laryngopharyngeal reflux events using hypopharyngeal multichannel intraluminal impedance (HMII). J Gastrointest Surg. 2012;16(1):16-24; discussion 24-15.
14. Wang AJ, Liang MJ, Jiang AY, et al. Gastroesophageal and laryngopharyngeal reflux detected by 24-hour combined impedance and pH monitoring in healthy Chinese volunteers. J Dig Dis.2011;12(3):173-180.
15. Kawamura O, Kohata Y, Kawami N, et al. Liquid-containing Refluxes and Acid Refluxes May Be Less Frequent in the Japanese Population Than in Other Populations: Normal Values of 24- hour Esophageal Impedance and pH Monitoring. J Neurogastroenterol Motil. 2016;22(4):620-629.
16. Kuo C-L. Laryngopharyngeal Reflux: An Update. Archives of Otorhinolaryngology-Head & Neck Surgery. 2019;3(1 %U https://scitemed.com/article/2594/scitemed-aohns-2019-00094).
17. Kang HJ, Park JM, Choi SY, et al. Comparison Between Manual and Automated Analyses in Multichannel Intraluminal Impedance: pH Monitoring for Laryngopharyngeal Reflux. Otolaryngol Head Neck Surg.2021:1945998211006929.
18. Park W, Hicks DM, Khandwala F, et al. Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response.Laryngoscope. 2005;115(7):1230-1238.
19. Yoon YH, Park KW, Lee SH, Park HS, Chang JW, Koo BS. Efficacy of three proton-pump inhibitor therapeutic strategies on laryngopharyngeal reflux disease; a prospective randomized double-blind study. Clin Otolaryngol. 2019;44(4):612-618.
20. Pandolfino JE, Zhang QG, Ghosh SK, Han A, Boniquit C, Kahrilas PJ. Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry.Gastroenterology. 2006;131(6):1725-1733.
21. Moonen A, Aguilera‐Lizarraga J, Bisschops R, Moonen P, Tack J, Boeckxstaens GE. 24‐hour multi‐pH recording of the postprandial acid pocket and the nocturnal acid distribution at the esophagogastric junction in healthy volunteers. Neurogastroenterology & Motility. 2019;31(11 %U https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.13694).
22. Schneider JH, Kuper MA, Konigsrainer A, Brucher BL. Transient lower esophageal sphincter relaxation and esophageal motor response. J Surg Res. 2010;159(2):714-719.
23. Szczesniak MM, Williams RB, Cook IJ. Mechanisms of Esophago-Pharyngeal Acid Regurgitation in Human Subjects. PLoS ONE. 2011;6(7):e22630 %U https://dx.plos.org/22610.21371/journal.pone.0022630.
24. Gourcerol G, Verin E, Leroi AM, Ducrotté P. Can multichannel intraluminal pH-impedance monitoring be limited to 3 hours? Comparison between ambulatory 24-hour and post-prandial 3-hour recording: Three-hour pH-impedance monitoring. Diseases of the Esophagus.2014;27(8):732-736 %U https://academic.oup.com/dote/article-lookup/doi/710.1111/dote.12161.
25. Merati AL, Lim HJ, Ulualp SO, Toohill RJ. Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux. Ann Otol Rhinol Laryngol.2005;114(3):177-182.
Table 1. Baseline characteristics of 69 enrolled subjects with laryngopharyngeal reflux