What this study adds
• The same dosing regimen of 40 mg.kg-1.d-1 showed better parameters of PK/PD, including a higher ratio of the area under the concentration-time curve over 24 h (AUC0–24 h) to the minimum inhibitory concentration (AUC0–24/MIC) and a more steady-state blood concentration in CIV compared to that in IIV.
• There was no difference in the clinical outcome and the rate of drug-related adverse effects between the two groups.