What is already known about this subject
• Vancomycin is conventionally used for treating severe gram-positive cocci infection in the pediatric intensive care unit.
•Prolonging the infusion time of vancomycin can improve its pharmacokinetics/pharmacodynamics (PK/PD) since it is a time-dependent drug.
• Very few trials have compared the effect of continuous infusions of vancomycin (CIV) to that of the intermittent infusions (IIV) in children on its PK/PD.