What this study adds
•
The same dosing regimen of 40
mg.kg-1.d-1 showed better parameters
of PK/PD, including a higher ratio
of the area under the concentration-time curve over 24 h
(AUC0–24 h) to the minimum inhibitory concentration
(AUC0–24/MIC) and a more steady-state blood
concentration in CIV compared to that in IIV.
• There was no difference in the clinical outcome and the rate of
drug-related adverse effects between the two groups.