2.1 GWAS summary data for BW and cancers
The public Genome-wide association study (GWAS) relative to BW we chose
was reported by Horikoshi M et al. in 2013 45. It
identified 60 loci associated with BW which was transformed into Z-score
separately in males and females excluding non-singletons and premature
births to standardize the data. All meta-analyses were derived from the
European population of Early Growth Genetics (EGG) Consortium. The lead
SNPs were up to the standard of the threshold of genome-wide
significance (P<5×10-8) and the limitation of the
linkage disequilibrium (LD) analysis (R2<0.05). To
identify the relationship between BW and different types of cancers, we
chose several GWAS meta-analyses including seven cancers. All the
population was from Europe and derived from the authoritative
consortium. (Table 1)