2.1 GWAS summary data for BW and cancers
The public Genome-wide association study (GWAS) relative to BW we chose was reported by Horikoshi M et al. in 2013 45. It identified 60 loci associated with BW which was transformed into Z-score separately in males and females excluding non-singletons and premature births to standardize the data. All meta-analyses were derived from the European population of Early Growth Genetics (EGG) Consortium. The lead SNPs were up to the standard of the threshold of genome-wide significance (P<5×10-8) and the limitation of the linkage disequilibrium (LD) analysis (R2<0.05). To identify the relationship between BW and different types of cancers, we chose several GWAS meta-analyses including seven cancers. All the population was from Europe and derived from the authoritative consortium. (Table 1)