First Author Year Country Median Age Assay Method Intestinal Bacteria TP FP FN TN Sample size Sensitivity Specificity PPV NPV PLR NLR
G. Serna et al. [26] 2020 Spain 71 RNA-ISH F. nucleatum 13 9 7 56 85 65.1% 86.2% 59.1% 88.9% 4.69 0.41
Sheng Zhang et al. [15] 2019 China 58 RT-PCR F. nucleatum 34 20 17 23 94 66.7% 53.5% 63.0% 57.5% 1.43 0.62
Tachung Yu et al. [14] 2017 China 62 RT-PCR F. nucleatum 58 21 29 65 173 66.7% 75.6% 73.4% 69.2% 2.73 0.44
Yanglong Chen et al. [27] 2019 China 59 droplet digital PCR F. nucleatum 25 20 17 29 91 59.5% 59.2% 55.6% 63.0% 1.46 0.68
Jing Li et al. [28] 2020 China 58 RT-PCR B. fragilis 22 13 17 7 59 56.4% 35.0% 62.9% 29.2% 0.87 1.25
Xingming Deng et al. [29] 2018 China 51 multiplex PCR B. fragilis 6 13 11 26 56 35.3% 66.7% 31.6% 70.3% 1.06 0.97
Jun Li et al. [30] 2020 China 59 RNA-ISH B. fragilis 54 36 48 12 150 52.9% 25.0% 60.0% 20.0% 0.71 1.88
John Nemunaitis et al. [31] 2013 America 52 RT-PCR E. coli 3 2 1 0 6 94.7% 13.8% 41.9% 80.0% 1.10 0.38
Clemens Unger et al. [32] 2001 Germany 62 droplet digital PCR E. coli 44 25 2 3 74 95.7% 10.7% 63.8% 60.0% 1.07 0.41
Maria Liljefors et al. [33] 2008 Sweden 63 RNA-ISH E. coli 31 68 4 4 107 88.6% 5.6% 31.3% 50.0% 0.94 2.06
Jeremy Shapiro et al. [34] 1999 America 56 multiplex PCR E. coli 42 147 3 5 197 93.3% 3.3% 22.2% 62.5% 0.97 2.03