3.2 Intraocular tissue damage
Intraocular tissue (lens and vitreous) damage caused by taxane is rare. Kuwata et al. [21] evaluated the ocular toxicity of different doses of paclitaxel to Sprague-Dawley (SD) rats of different ages. The results showed that the dose of 4 or 8 mg/kg of PTX injected into 0-day-old rats resulted in epithelial cells of the lens apoptotic, and the lens fibers were degenerative on the 7th day. These phenomena suggested the occurrence of cataract. However, no ocular lesions were observed at the dose of 2 mg/kg of PTX injected into 0-day-old rats. At the same time, no ocular lesions were observed in rats injected intraperitoneally with 4 mg/kg paclitaxel at 14 days of age and 8 mg/kg paclitaxel at 12 to 18 weeks of age. These results suggested that the ocular toxicity of paclitaxel may be dose-related and age-related, and attention should be paid to the ocular toxicity of paclitaxel in early developmental stage. But the mechanisms are still under water.