5 Conclusion
The adverse ocular side effects of taxane drugs mainly appear on the
ocular surface, ocular appendage and intraocular tissue structure, with
various clinical manifestations such as dry eye, conjunctivitis,
keratitis, macular edema, retinal injury, optic nerve injury, and etc.
The hidden mechanisms remain elusive. The macular edema induced by
taxane drugs may be related to the dysfunction of retinal pigment
epithelial cells and Müller cells, and other adverse reactions may be
related to the cytotoxicity of paclitaxel. Before the application of
paclitaxel drugs, baseline examination of ophthalmology is necessary.
Ocular symptoms should be closely observed during the administration.
Eye adverse reactions can be clearly diagnosed through routine
ophthalmic examination. Once found, chemotherapy should be considered to
be adjusted according to comprehensive evaluation, and symptomatic
treatment can be given, so as to avoid irreversible eye injuries.