3.2 Intraocular tissue damage
Intraocular tissue (lens and vitreous) damage caused by taxane is rare.
Kuwata et al. [21] evaluated the
ocular toxicity of different doses of paclitaxel to Sprague-Dawley (SD)
rats of different ages. The results showed that
the dose of 4 or 8 mg/kg of PTX
injected into 0-day-old rats resulted in epithelial cells of the lens
apoptotic, and the lens fibers were degenerative on the 7th day. These
phenomena suggested the occurrence of cataract. However, no ocular
lesions were observed at the dose of 2 mg/kg of PTX injected into
0-day-old rats. At the same time, no ocular lesions were observed in
rats injected intraperitoneally with 4 mg/kg paclitaxel at 14 days of
age and 8 mg/kg paclitaxel at 12 to 18 weeks of age. These results
suggested that the ocular toxicity of paclitaxel may be dose-related and
age-related, and attention should be paid to the ocular toxicity of
paclitaxel in early developmental stage. But the mechanisms are still
under water.