Ye Ya-ting1,2,#, Zhou
Zi-yi1,#, Wen Li-shi, Sun yu2, Chu
Zhao-jie2,3,*, Dou Guo-rui1,*
1
Department
of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital,
Fourth Military Medical University,
Xi′an 710032, China
2 Department of Chinese Materia Medica, College of Life Sciences,
Northwestern University, Xi′an 710069, China
3 Department of Ophthalmology, the First Affiliated Hospital of
Northwest University (Xi′an First Hospital), Xi′an 710002, China
* CorrespondenceGuo-Rui Dou
Tel: 029-84771273 Email:
fierywang@126.com
Tel: 18629620056 Email: chuzhaojie2009@163.com
# Equally contributed to this manuscript
【Abstract】 The adverse ocular reactions to paclitaxels involve
a series of damage, which can be observed on ocular surface, ocular
appendages and intraocular tissues. They can appear as various clinical
symptoms including dry eye, lacrimal duct obstruction, conjunctivitis,
keratitis, macular edema, retinal injury, optic nerve injury, and etc.
All these symptoms may lead to irreversible visual loss. The mechanisms
of these side effects are still unclear. Macular edema, one of the side
effects, may be related to the dysfunction of retinal pigment epithelial
(RPE) cells and Müller cells which is caused by paclitaxel, while other
symptoms may be caused by the cytotoxicity of paclitaxels. In this
review, we describe the widely accepted drug-induced ocular disorders
and the possible mechanisms, so as to provide some suggestions for the
monitoring and management of ocular toxicity.
【Key words】 Paclitaxel, Eye diseases, Drug related
side effects and adverse reactions
As the first natural phytochemical drug approved by Food and Drug
Administration (FDA), Paclitaxel (Taxol) is an anti-tumor drug with
highly efficacy and low toxicity. As taxane widely served as an
anti-tumor drug, the number of reports on its adverse side effects is
climbing rapidly, mainly including bone marrow suppression, allergic
reaction, digestive system reaction, numbness of the hand and foot,
liver injury, and etc. However, in recent years, there have been reports
of adverse ocular reactions caused by taxane drugs. Such as vision loss
[1], dry eye [2], lacrimal duct obstruction [3],
conjunctivitis [4], glaucoma [5], optic neuropathy [6],
macular edema [7, 8], blindness caused by combination with cisplatin
[9], and so on. These adverse side effects have numerous effects on
patients’ life quality and their compliance to the therapy. In order to
have a comprehensive understanding of the ocular adverse sides caused by
taxane drugs as well as and their possible mechanisms in side effects
and to improve the safety of the administration, we briefly reviewed the
relevant literatures at home and abroad.