5 Conclusion
The adverse ocular side effects of taxane drugs mainly appear on the ocular surface, ocular appendage and intraocular tissue structure, with various clinical manifestations such as dry eye, conjunctivitis, keratitis, macular edema, retinal injury, optic nerve injury, and etc. The hidden mechanisms remain elusive. The macular edema induced by taxane drugs may be related to the dysfunction of retinal pigment epithelial cells and Müller cells, and other adverse reactions may be related to the cytotoxicity of paclitaxel. Before the application of paclitaxel drugs, baseline examination of ophthalmology is necessary. Ocular symptoms should be closely observed during the administration. Eye adverse reactions can be clearly diagnosed through routine ophthalmic examination. Once found, chemotherapy should be considered to be adjusted according to comprehensive evaluation, and symptomatic treatment can be given, so as to avoid irreversible eye injuries.